Plenary Session, Award- or Invited Lecture
PS-003
Evolution in Medicinal Chemistry (KGF-SCS Distinguished Industrial Science Award Lecture 2015)
J. Zimmermann1
1Novartis Institutes for Biomedical Research, Novartis, Basel, Switzerland
Medicinal chemistry is the chemistry discipline concerned with the design, development and synthesis of pharmaceutical drugs. It evolved from organic chemistry and its roots can be traced back at least hundred years to Ehrlich and others in Europe. Over the past 25 years, medicinal chemistry has gone through major changes as will be shown in the talk. Targets known as undrugable in the past are today the focus of modern medicinal chemistry. The molecular weight of the molecules synthesized increases significantly going from low-molecular weight heterocycles to antibodies, vaccines and proteins. In addition the batch mode is in some cases being replaced by flow-chemistry. Examples from our organizations will be presented and discussed.
In the above picture, a protein – protein interaction is shown with its huge interacting surface. The challenge for the rather small “LMW” to interrupt this interaction is clearly visible. Projects where the inhibition of these interactions is required are today the focus in many medicinal chemistry activities.